Triple-Quantum-Filtered Sodium MRI of the Human Brain at 4.7T

Adrian Tsang¹, Rob Stobbe¹, Christian Beaulieu¹

Triple-quantum-filtered (TQF) MRI for imaging microscopic ordered tissue sodium, presumably mainly intra-cellular, is challenging due to the limited signal-to-noise ratio and has only ever been applied once to in vivo human brain at 3T. The goal of our study is to improve the image quality of the triple quantum filtered sodium brain images by utilizing modified 3D twisted projection imaging with the higher static magnetic field strength of 4.7T. We show that TQF sodium MRI is achievable in a reasonable 11 min with adequate resolution to delineate brain structures such as the ventricles.