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Abstract #4356

Evaluation of Severe Anemia by Quantitatively Measuring Multi-Organ Oxygen Using 19 F MRI in a Rat Model

Siyuan Liu1,2, Sameer J. Shah2, Lisa J. Wilmes1, Vikram Kodibagkar3, Michael F. Wendland1, Nola Hylton1, Harriet W. Hopf4, Ralph P. Mason3, Mark D. Rollins2

1Radiology, University of California, San Francisco, San Francisco, CA, USA; 2Anesthesia, University of California, San Francisco, San Francisco, CA, USA; 3Radiology, University of Texas at Southwestern, Dallas, TX, USA; 4Anesthesia, University of Utah, Salt Lake City, UT, USA

Supplemental oxygen is often given to anemic patients, yet the changes in individual organ pO2 from anemia and hyperoxia are poorly quantified. We used 19F MRI to measure the effects of severe anemia and hyperoxia on individual rat organs using a 7T system, 19F/1H volume coil, and FREDOM sequence. The pO2 in all organs examined decreased a small, quantifiable amount with severe isovolemic anemia, and increased above baseline values with inspiration of 100% oxygen. Preliminary findings suggest supplemental oxygen effectively increases organ oxygenation during anemia, and the 19F MRI method is valuable in quantifying the effectiveness of various resuscitation interventions.