Ilwoo Park1,2, Peder E. Larson2, Janine M. Lupo2, Robert Bok2, Tomoko Ozawa3, John Kurhanewicz1,2, Daniel B. Vigneron1,2, C David James3, Sarah J. Nelson1,2
1Bioengineering, University of California, San Francisco/Berkeley, San Francisco, CA, USA; 2Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; 3Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
We have applied slice-localized 13C Dynamic MR Spectroscopy and 2D 13C multiband dynamic MR spectroscopic imaging following injection of hyperpolarized [1-13C]-pyruvate in order to monitor the real time metabolic dynamics of a human glioblastoma xenograft in rat model. The 2D dynamic CSI provided spatially resolved MRS that allowed for the differentiation of tumor from normal tissue based on the conversion of pyruvate to lactate. The results from this study showed potential for applying time-resolved MR spectroscopic imaging to characterize brain tumor models.