Abstract #4376

Application of Slice-Localized 13C Dynamic MR Spectroscopy and 2D 13C Dynamic MR Spectroscopic Imaging with Hyperpolarized [1-13C]-Pyruvate in a Human Glioblastoma Xenograft

Ilwoo Park^1,2, Peder E. Larson², Janine M. Lupo², Robert Bok², Tomoko Ozawa³, John Kurhanewicz^1,2, Daniel B. Vigneron^1,2, C David James³, Sarah J. Nelson^1,2

¹Bioengineering, University of California, San Francisco/Berkeley, San Francisco, CA, USA; ²Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; ³Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA

We have applied slice-localized ¹³C Dynamic MR Spectroscopy and 2D ¹³C multiband dynamic MR spectroscopic imaging following injection of hyperpolarized [1-¹³C]-pyruvate in order to monitor the real time metabolic dynamics of a human glioblastoma xenograft in rat model. The 2D dynamic CSI provided spatially resolved MRS that allowed for the differentiation of tumor from normal tissue based on the conversion of pyruvate to lactate. The results from this study showed potential for applying time-resolved MR spectroscopic imaging to characterize brain tumor models.