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Abstract #4384

Selective Saturation of Xe Dissolved Into Tissue and Xe Bound with Hemoglobin in Human Lungs in Hyperpolarized 129Xe MR

Yulin Chang1, Talissa A. Altes1, Isabel M. Dregely2, Stephen Ketel3, Iulian C. Ruset2,3, Jaime F. Mata1, F. William Hersman2,3, John P. Mugler III1, Kai Ruppert1

1Radiology, University of Virginia, Charlottesville, VA, USA; 2Physics, University of New Hampshire, Durham, NH, USA; 3Xemed LLC, Durham, NH, USA

In humans Xe dissolved into lung tissue and Xe bound with hemoglobin have distinct resonance frequencies at 197 ppm and 217 ppm, respectively. In studies of the gas exchange processes in the lung it is often desirable to selectively saturate either individual dissolved-phase peak. RF pulses centering at various frequencies and with different pulse durations were tested at both 1.5 T and 2.9 T fields for this purpose.