Abstract #4384

Selective Saturation of Xe Dissolved Into Tissue and Xe Bound with Hemoglobin in Human Lungs in Hyperpolarized 129Xe MR

Yulin Chang¹, Talissa A. Altes¹, Isabel M. Dregely², Stephen Ketel³, Iulian C. Ruset^2,3, Jaime F. Mata¹, F. William Hersman^2,3, John P. Mugler III¹, Kai Ruppert¹

¹Radiology, University of Virginia, Charlottesville, VA, USA; ²Physics, University of New Hampshire, Durham, NH, USA; ³Xemed LLC, Durham, NH, USA

In humans Xe dissolved into lung tissue and Xe bound with hemoglobin have distinct resonance frequencies at 197 ppm and 217 ppm, respectively. In studies of the gas exchange processes in the lung it is often desirable to selectively saturate either individual dissolved-phase peak. RF pulses centering at various frequencies and with different pulse durations were tested at both 1.5 T and 2.9 T fields for this purpose.