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Abstract #4453

Towards Whole-Brain Quantitative T1 Mapping at 3.0T for Imaging Hippocampal Sclerosis

Rebecca Sara Samson1, Mark R. Symms2, Mahinda Yogarajah2, Niels Focke2, John S. Duncan2

1Department of Neuroinflammation, UCL Institute of Neurology, London, UK; 2Department of Clinical & Experimental Epilepsy, UCL Institute of Neurology, London, UK

This study aimed to establish the normal variation in T1 measurements made using a 3D, whole-brain T1 mapping method at 3.0T with a view to applying the technique in Hippocampal Sclerosis. Measured T1 values are consistent with literature and inter- and intra-subject variation were demonstrated to be uniformly low, indicating the potential of this method for clinical applications, including imaging the hippocampus. T1 mapping in Hippocampal Sclerosis may provide complementary information to the well-established technique of T2 measurement.