Meeting Banner
Abstract #4457

Quantification of SPIO Using T2* and Phase Imaging

Alexia Rodrguez-Ruano1, Marina Benito1, Cristina Santa Marta2, Gema Elvira3, Paula Montesinos1, Juan Jose Vaquero1, Augusto Silva3, Manuel Desco1,4

1Medicina y Ciruga Experimental, Hospital General Universitario Gregorio Maran, Madrid, Spain; 2Dept. Fsica Matemtica y Fluidos, Universidad Nacional de Educacin a Distancia (UNED), Madrid, Spain; 3Cancer Genetics and Cancer Stem Cells Laboratory, Centre of Biological Research (CIB-CSIC), Madrid, Spain; 4Centro de investigacin en red en salud mental (CIBERSAM), Madrid, Spain

Quantification in susceptibility imaging is becoming a request for many applications. Susceptibility effects have been studied mainly from two approaches, SWI and T2* relaxometry. However, most of the studies using these techniques were not particularly concerned with quantification issues. We have assessed the sensitivity and quantification ability of these techniques by comparing the measurements obtained using different types of images with the concentration of SPIO particles in the sample, using an agar phantom with different iron concentrations. Phase image contrast results in a linear relation with iron concentration similar to that obtained with T2* map, while requiring shorter acquisition time.