Meeting Banner
Abstract #4468

Multi-Echo Spin-Echo (MESE) Signal Behavior of Paramagnetic Holmium-166 Loaded Microspheres for Radiotherapy: Experiment and Simulation

Gerrit Hendrik van de Maat1, Peter R. Seevinck1, Koen L. Vincken1, Hendrik de Leeuw1, Chris J. Bakker1,2

1Image Sciences Institute, University Medical Centre Utrecht, Utrecht, Netherlands; 2Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands

The potential of multi-echo spin-echo (MESE) measurements for quantification of holmium-166 loaded microspheres (HoMS) was explored. This was done by investigating the signal decay due to HoMS by MR experiments on a gel series containing HoMS and by Monte Carlo simulations. Results were compared to the theoretical model of strong field behavior and appeared to be in good agreement for a wide range of HoMS concentrations. The study indicates the potential of MESE for the quantification of HoMS concentrations up to 20mg/ml.