Ying Wu1,2, Hongyan Du3, Kelly H. Zou4, Shawn Sidharthan1, Eugene Dunkle, Robert Edelman1,2, Ann Ragin2
1Radiology, NorthShore University HealthSystem, Evanston, IL, USA; 2Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 3Center on Outcomes, Research and Education, NorthShore University HealthSystem, Evanston, IL, USA; 4Global Medical R&D, Pfizer Inc, New York, NY, USA
The validity of quantitative MR methods for monitoring progression in Multiple Sclerosis, Alzheimers Disease and other chronic neurological diseases is limited by the reliability and reproducibility of the derived measurements. This investigation evaluated the reliability and reproducibility of a promising new high resolution strategy based on quantitative MT. The strategy was evaluated using conventional manually-defined region of interest measurements. In addition, the reliability and reproducibility of high resolution quantitative MT was also evaluated using automated methods aimed at eliminating operator bias further.