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Abstract #4474

Intra- And Inter-Scanner Variability of Magnetization Transfer Ratio Using Balanced SSFP

Monika Gloor1, Klaus Scheffler1, Oliver Bieri1

1Radiological Physics, University of Basel Hospital, Basel, Switzerland

Magnetization transfer ratio (MTR) has become an important tool to study various tissue abnormalities, such as demyelination in brain white matter. Recently, a new technique for measuring MTR has been proposed based on balanced steady-state free precession (bSSFP) with modified radiofrequency pulses. The reproducibility and variability of MTR-bSSFP was analyzed on six healthy volunteers using two different 1.5T clinical systems. Intra-scanner MTR measurements were well reproducible (< 0.3 pu) and inter-scanner variation is below 0.5 pu for optimal flip angle settings ([pu]: percentage units). MTR-bSSFP benefits further from relatively low B1 sensitivity, high signal-to-noise ratios, and short overall acquisition times.