Meeting Banner
Abstract #4498

Amide Proton Transfer (APT) MRI: A 3T Vs. 7T Comparison

Guang Jia1, Jinyuan Zhou2, Seongjin Choi1, Wenbo Wei1, Steffen Sammet1, Daniel James Clark1, Stefan Fischer3, Michael V. Knopp1

1Department of Radiology, The Ohio State University, Columbus, OH, USA; 2Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; 3Philips Medical Systems, Cleveland, OH, USA

The frequency difference between amide proton (3.5 ppm) and water resonance is 1043 Hz at 7T, much greater than 448 Hz at 3T, which may help reduce mixture of APT-MTR with the direct saturation effect to water signal. Our results shows better separation between the amide proton saturation and free water saturation profiles and a clearer dip that reflects the APT effect in the MT-spectrum of egg white at 7T than that at 3T. This study strongly suggests that the APT sequence should be extensively evaluated at ultra-high-field (7T) for tissue characterization.