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Abstract #4530

Intra and Inter-Site Reproducibility of Myelin Water Volume Fraction Values Derived Using McDESPOT

Sean CL Deoni1, Rebecca Samson2, Claudia A.M. Wheeler-Kingshot2

1Centre for Neuroimaging Sciences, London, UK; 2Department of Neuroinflammation, UCL Institute of Neurology, London, UK

Multi-component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) is a promising alternative to conventional T2-based approaches to multi-component relaxometry. An important attribute of any quantitative imaging method is the techniques reproducibility, both across multiple time-points and across different imaging centres. Here we quantify the intra and inter-site reproducibility of mcDESPOT-derived myelin water volume fraction estimates, demonstrating high repeatability with intra and inter-site coefficients of variations of 0.069 and 0.07, respectively. Further, voxel-wise paired t-tests revealed no time-point or imaging site-specific biases.