Comparison of Prospective ECG-Gated MRI with Wireless, Retrospective Gated MRI for Evaluation of Heart Function in Healthy and Infarcted Mouse Heart

Sandra Margaretha Bovens^1,2, Bernard C. te Boekhorst¹, Krista den Ouden¹, Kees W. van de Kolk¹, Arno Nauerth³, Marcel G. Nederhoff^1,2, Gerard Pasterkamp¹, Michiel ten Hove¹, Cees J. van Echteld⁴

To assess (murine) left- and right ventricular heart function, ECG-triggered CMRI is often used. In mice with a myocardial infarction or cardiac hypertrophy it is sometimes challenging to get a good ECG signal. Therefore we compared a wireless retrospective gating method with a prospective gating method in mice with and without infarcted hearts. The SNR and CNR of the retrospectively gated data are higher than that of the prospectively gated data. The wireless retrospective gating method gives comparable results with regard to the cardiac function parameters, in the control mice as well as the mice with myocardial infarction.