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Abstract #4580

Comparison of Prospective ECG-Gated MRI with Wireless, Retrospective Gated MRI for Evaluation of Heart Function in Healthy and Infarcted Mouse Heart

Sandra Margaretha Bovens1,2, Bernard C. te Boekhorst1, Krista den Ouden1, Kees W. van de Kolk1, Arno Nauerth3, Marcel G. Nederhoff1,2, Gerard Pasterkamp1, Michiel ten Hove1, Cees J. van Echteld4

1Cardiology, University Medical Center Utrecht, Utrecht, Netherlands; 2InterUniversity Cardiology Institute of the Netherlands, Utrecht, Netherlands; 3Bruker Biospin MRI GmbH, Germany; 4Novartis Institutes for BioMedical Research, Basel, Switzerland

To assess (murine) left- and right ventricular heart function, ECG-triggered CMRI is often used. In mice with a myocardial infarction or cardiac hypertrophy it is sometimes challenging to get a good ECG signal. Therefore we compared a wireless retrospective gating method with a prospective gating method in mice with and without infarcted hearts. The SNR and CNR of the retrospectively gated data are higher than that of the prospectively gated data. The wireless retrospective gating method gives comparable results with regard to the cardiac function parameters, in the control mice as well as the mice with myocardial infarction.