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Abstract #4661

Impact of B1 Inhomogeneities on AIF Selection in DCE-MRI at 3 Tesla

Robert Merwa1, Gernot Reishofer2, Thorsten Feiweier3, Karin Kapp4, Franz Ebner2, Rudolf Stollberger1

1Institute of Medical Engineering, Graz University of Technology, Graz, Austria; 2Department of Radiology, Medical University of Graz, Graz, Austria; 3MED MR PLM AW Neurology, Siemens AG Healthcare Sector, Erlangen, Germany; 4Department of Radiation Therapy, Medical University of Graz, Graz, Austria

Dynamic contrast-enhanced MRI was performed in combination with a special sequence in order to determine B1 inhomogenities. AIF and tissue concentrations were calculated and the kinetic parameters Ktrans and Ve were determined with a generalized kinetic model. The absolute deviation of the maximum values of two comparable AIFs can be improved by a factor greater than 10 and the root mean square deviation concerning the two AIFs can be decreased by a factor greater than 5 if B1 inhomogeneities are corrected. Also the deviations of Ktrans and Ve in respect of the two AIFs are significantly lower.