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Abstract #4689

Demonstration of a Novel Edge Analysis Technique Using a Purpose Built MR Phantom

Robert Allan Brown1,2, Ashley D. Harris1,2, Richard Frayne2,3

1Biomedical Engineering, University of Calgary, Calgary, AB, Canada; 2Seaman Family MR Research Centre, University of Calgary, Calgary, AB, Canada; 3Radiology and Clinical Neurociences, University of Calgary, Calgary, AB, Canada

In many diseases, the interface between diseased and healthy tissue may contain a great deal of information. One example is the brain tumor oligodendroglioma, where characteristics of the tumor margin are significantly associated with 1p/19q co-deletion, which is a marker for good response to chemo- and radiation-therapy. In this abstract we report the design of a phantom to simulate invasive and non-invasive tissue border properties, and use a novel edge analysis technique to quantify these features.