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Abstract #4706

Calculation of Optic Nerve Dimensions Using Gaussian Fitting of MR Images

Li Sze Chow1, Lauren Wallis1, Nigel Hoggard1, Simon J. Hickman2, Martyn N.J. Paley1

1Academic Unit of Radiology, University of Sheffield, Sheffield, UK; 2Department of Neurology, The Sheffield Royal Hallamshire Hospital, Sheffield, UK

The aim of this study was to develop a program to accurately calculate the optic nerve diameter, area and volume using Gaussian fitting of the acquired MR images. The program will be used in a new study of optic neuritis on 1.5T and 3.0T MR systems with both T1- and T2-weighted 3D Spectral Presaturation Inversion Recovery (SPIR) sequences and much shorter scan times. This study has also shown that T2W images are suitable for measuring the actual optic nerves dimension; whereas T1W images can be used to measure the optic nerve and the sheath and CSF surrounding the nerve.