Mahinda Yogarajah1, Niels Focke2,
Silvia Bonelli1, Pam Thompson1, Christian Vollmar1,
Andrew McEvoy3, Mark Symms1, Matthias Koepp1,
1MRI Unit, National Society for
Epilepsy, Chalfont St Peter, Bucks, United Kingdom; 2University of
Goettingen, Germany; 3University College London Hospital, United
is the most chronic, common neurological condition. Many patients with temporal lobe epilepsy
undergo anterior temporal lobe resection, but up to 40% of patients are at
risk of language decline after surgery.
We carried out a longitudinal study using diffusion tensor imaging to
assess the structural reorganisation of white matter after surgery. In patients undergoing surgery in the
language dominant hemisphere, there is an increase in FA in white matter
connecting fronto-temporal regions.
The location of these increases and their correlation with language
function suggest they may represent the structural plasticity of language
networks after surgery.