Laura Serra1, Mara Cercignani1, Roberta Perri2, Barbara Span1, Lucia Fadda2,3, Camillo Marra4, Franco Giubilei5, Carlo Caltagirone2,6, Marco Bozzali1
1Neuroimaging laboratory, Fondazione IRCCS Santa Lucia, Roma, Italy; 2Department of Clinical and Behavioural Neurology, Fondazione IRCCS Santa Lucia, Roma, Italy; 3Department of Neuroscience, , University of Rome Tor Vergata, Rome, Italy; 4Institute of Neurology, Universit Cattolica, Roma, Italy; 5Department of Neurology, II Faculty of Medicine University of Rome, Sapienza, Rome, Italy; 6Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
The uncinate fasciculus (UF) connects temporal and frontal regions, traditionally implicated by pathological damage in dementia. We aimed at assessing, using DTI and tractography, the role of UF damage in the progression from mild cognitive impairment (MCI) to Alzheimers disease (AD), and whether its involvement could distinguish between patients with AD and patients with dementia with Lewy Bodies (DLB). Fractional anisotropy was significantly reduced only in the UF of demented patients as compared to both, HS and a-MCI patients. This suggests that UF involvement is relevant for the development dementia, but it does not distinguish between AD and DLB.