Meeting Banner
Abstract #0022

Increases in CBF by Donepezil Treatment Enhance Cingulate Functional Network Activity in Mild Alzheimers Disease

Wenjun Li1, Chunming Xie1,2, Jennifer Jones3, Malgorzata Franczak3, Piero Antuono3, Shi-jiang Li1

1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Neurology, Southeast University, Nanjing, Jiansu, China,; 3Neurology, Medical College of Wisconsin, Milwaukee, WI, United States

Cholinergic inhibitor (AriceptĀ®) has been shown to improve cognitive function in adults with Alzheimers disease (AD). Also, it has an effect on improving the cerebral blood flow (CBF) perfusion detected by PET technology. Previously we have found increased CBF in cingulate and posterior cingulated regions using a Pseudo-Continuous Arterial Spin Labeling (pCASL) MR technique. It is hypothesized that the increase in CBF after treatment could alter functional connectivity in related neural networks. The aim of the current study is to determine the changes in the functional connectivity in networks with significantly increased CBF after the drug treatment.