He Zhu1,2, Ronald Ouwerkerk1,3, Richard A.E. Edden1,2, Peter B. Barker1,2
1Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3The National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States
A spin echo based MEGA-MRSI sequence was developed to acquire MEGA-edited spectra of γ-aminobutyric acid (GABA) in an entire slice with excellent sensitivity. Co-editing of lipid and NAA signals was greatly suppressed by a dualband pre-saturation sequence and integrated outer volume suppression (OVS) pulses. Experiments in normal volunteers were performed at 3 Tesla using a 32-channel head coil. High signal-to-noise ratio spectra and metabolic images of GABA (and glutamate) were acquired from 4.5 cm3 voxels in a scan time of 17 minutes.