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Abstract #0098

Diffusion-Weighted MR Imaging of Kidneys Using Targeted-SPLICE

Ning Jin1, Jie Deng2, Andrew C. Larson1,3

1Departments of Radiology and Biomedical Engineering, Northwestern University, Chicago, IL, United States; 2Children's Memorial Hospital, Chicago, IL, United States; 3Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, United States

Diffusion-weighted (DW) imaging is particularly useful for functional interrogation of the kidney. Single-shot DW spin-echo echo-planner imaging (DW-SE-EPI) is commonly used for DW acquisition; however, this technique can experience image distortion and chemical shift artifacts. We recently developed targeted-SPLICE technique by combining the inner volume imaging technique with SPLICE for DWI without image distortion and blurring. The purpose of our study is to apply targeted-SPLICE technique for DWI in the kidneys and compare these targeted-SPLICE diffusion measurements to conventional DW-SE-EPI measurements. Targeted-SPLICE effectively reduced geometric distortion and image blurring and produced accurate diffusion parameter measurements in the kidney.