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Abstract #0128

Hemodynamic and Metabolic Response to Hypoxia

Ashley D. Harris1, Richard A. E. Edden2,3, Kevin Murphy1, C John Evans1, Chen Y. Poon4, Neeraj Saxena5, Judith Hall5, Thomas T. Liu6, Damian M. Bailey7, Richard G. Wise1

1Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom; 2Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States; 3Cardiff University Brain Imaging Research Centre (CUBRIC) and Schools of Chemistry and Biosciences, Cardiff University, Cardiff, United Kingdom; 4School of Medicine, Cardiff University, Cardiff, United Kingdom; 5Anaesthetics and Intensive Care Medicine, Cardiff University, Cardiff, United Kingdom; 6Center for Functional MRI (fMRI), University of California, San Diego, San Diego, CA, United States; 7Health, Sport and Science, University of Glamorgan, Mid-Glamorgan, United Kingdom

MR spectroscopy to examine lactate and ASL perfusion imaging are used to study the response to 12% hypoxia in healthy subjects. Lactate and cerebral blood flow increased during hypoxia. Both lactate and blood flow are negatively related to oxygen saturation. The relationship between increased perfusion and lactate accumulation appears to be more complex; however, by understanding these relationships, we may gain insight into cerebral pathologies and conditions that result in hypoxemia.