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Abstract #0151

Evaluation of the Relationship Between LSO2 MR Measurement and Hypoxia : Impact of an Antiangiogenic Treatment on a Gliosarcoma Model

Benjamin Lemasson1, Thomas Christen1,2, Raphal Serduc3, Cecile Maisin1, Audrey Bouchet3, Christopoh Segebarth1, Graldine Le Duc3, Chantal Rmy1, Emmanuel Louis Barbier1

1Inersm U836, Grenoble, France; 2Universit Joseph Fourier, Grenoble Institut des Neurosciences, Grenoble, France; 3ESRF, Grenoble, France

Despite a highly vascular phenotype, most glioblastomas cells are in hypoxia. Monitoring of hypoxia could be useful for monitoring the effectiveness of anti-tumor therapies. In this study, we evaluate (i) the relationship between the oxygenation (lSO2) estimated by MRI and tissue hypoxia estimated by immunohistology and (ii) the impact of an antiangiogenic (Sorafenib) treatment on the vasculature (Blood volume fraction; BVf) and the lSO2 of gliosarcoma model (9L). lSO2 estimate by MRI was correlated to tumor hypoxia observed by immunohistochimistry. Results of this study also suggest that lSO2 could be a sensitive reporter of the hypoxic effects of antiangiogenic therapies.