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Abstract #0169

Quantification of Myocardial Triglycerides: Ex-Vivo and In-Vivo Evaluations by Two-Point Water-Fat Imaging and 1H Spectroscopy

Chia-Ying Liu1, Alban Redheuil1, Ronald Ouwerkerk2, Charles Steenbergen3, Shenghan Lai4, Joao Lima1, David Bluemke5

1Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, United States; 2The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States; 3Department of Pathology, The Johns Hopkins University, Baltimore, MD, United States; 4Department of Epidemiology, Johns Hopkins School of Hygiene and Public health, Baltimore, MD, United States; 5Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States

The concept of fat contained within the myocardium, has recently received attention because of its potential role in diabetic myocardial disease, obesity, and HIV infected individuals. Measurements of myocardial triglycerides in humans have been accessed using proton MR spectroscopy (1H MRS). We studied the accuracy of the dual-echo Dixon MRI in quantifying the fatty content of the myocardium in autopsies and patients. 1H MRS as an independent method was also applied for comparison.