Abstract #0169

Quantification of Myocardial Triglycerides: Ex-Vivo and In-Vivo Evaluations by Two-Point Water-Fat Imaging and 1H Spectroscopy

Chia-Ying Liu¹, Alban Redheuil¹, Ronald Ouwerkerk², Charles Steenbergen³, Shenghan Lai⁴, Joao Lima¹, David Bluemke⁵

¹Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, United States; ²The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States; ³Department of Pathology, The Johns Hopkins University, Baltimore, MD, United States; ⁴Department of Epidemiology, Johns Hopkins School of Hygiene and Public health, Baltimore, MD, United States; ⁵Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States

The concept of fat contained within the myocardium, has recently received attention because of its potential role in diabetic myocardial disease, obesity, and HIV infected individuals. Measurements of myocardial triglycerides in humans have been accessed using proton MR spectroscopy (1H MRS). We studied the accuracy of the dual-echo Dixon MRI in quantifying the fatty content of the myocardium in autopsies and patients. 1H MRS as an independent method was also applied for comparison.