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Abstract #0185

ATP Production by Oxidative Metabolism and Blood Flow Augmentation by Non-Oxidative Glycolysis in Activated Human Visual Cortex

Ai-Ling Lin1, Jia-Hong Gao2, Timothy Q. Duong1, Peter T. Fox1

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Brain Research Imaging Center, University of Chicago, Chicago, IL, United States

The purpose of the study was to investigate the contributions of oxidative verses non-oxidative metabolism to (1) ATP (energy) production (JATP); and (2) cerebral blood flow (CBF) augmentation, during neuronal activation. Cerebral oxygen metabolic rate, blood flow and lactate concentration were determined using concurrent fMRI and 1H MRS with visual stimulations at different flickering frequencies. Our results provide additional supportive evidences that (1)the energy demand for brain activations is small and is met through oxidative metabolism; and (2) CBF can be regulated by non-oxidative glycolysis, rather than by oxygen demand.