Stephen J. Kadlecek1, Puttisarn
Mongkolwisetwara1, Kiarash Emami1, Masaru Ishii2,
Jianliang Zhu3, Elaine Chia1, John M. Woodburn1,
Rahim R. Rizi1
1Department of Radiology, University of
Pennsylvania, Philadelphia, PA, United States; 2Department of
Otolaryngology, Johns Hopkins University, Baltimore, MD, United States; 3Department
of Surgery, University of Pennsylvania, Philadelphia, PA, United States
Measurement
of pulmonary oxygen concentration in small animals using hyperpolarized gas
is shown to be complicated by gas redistribution during the short
breath-hold. This additional
complexity can be incorporated into a model which yields information about
airway obstruction and is potentially itself of diagnostic value.