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Abstract #0202

Measurement of Gas Flow and Oxygenation in Small Animal Lungs Using Hyperpolarized Gas

Stephen J. Kadlecek1, Puttisarn Mongkolwisetwara1, Kiarash Emami1, Masaru Ishii2, Jianliang Zhu3, Elaine Chia1, John M. Woodburn1, Rahim R. Rizi1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Otolaryngology, Johns Hopkins University, Baltimore, MD, United States; 3Department of Surgery, University of Pennsylvania, Philadelphia, PA, United States

Measurement of pulmonary oxygen concentration in small animals using hyperpolarized gas is shown to be complicated by gas redistribution during the short breath-hold. This additional complexity can be incorporated into a model which yields information about airway obstruction and is potentially itself of diagnostic value.