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Abstract #0231

MRI of Bioregenerative Approaches in Cartilage Repair: Differentiation of Repair Tissue After Matrix-Associated Autologous Chondrocyte Transplantation Using a Hyaloronic Acid-Based or a Collagen-Based Scaffold with Advanced Morphological Scoring and Bioch

Goetz Hannes Welsch1,2, Tallal Charles Mamisch3, Lukas Zak4, Matthias Blanke2, Alexander Olk2, Stefan Marlovits4, Siegfried Trattnig1

1MR Center, Department of Radiology, Medical University of Vienna, Vienna, Austria; 2Department of Trauma and Orthpaedic Surgery, University Hospital of Erlangen, Erlangen, Germany; 3Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland; 4Center for Joints and Cartilage, Department of Trauma Surgery, Medical University of Vienna, Vienna, Austria

Aim of the study was to compare cartilage repair tissue at the femoral condyle noninvasively after matrix-associated autologous chondrocyte transplantation (MACT) using Hyalograft C (HC), a hyaloronic acid-based scaffold, to cartilage repair tissue after MACT using CaReS, a collagen-based scaffold, with morphological and biochemical MRI. Differences in the surface of the repair tissue using morphological MRI and higher T2 values for the cartilage repair tissue depicted by biochemical T2 maps indicate differences in the composition of the repair tissue that was based on a collagen scaffold (CaReS), compared to the hyaloronic acid-based scaffold (HC), even two years post-implantation.