Peter Roland Seevinck1, Tim C. de Wit2, Gerrit Hendrik van de Maat1, Maarten A.D. Vente3, Mattijs Elschot3, Mark Konijnenberg4, Johannes F.W. Nijsen3, Chris JG Bakker1,2
1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Dept. of Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 3Dept. of Nucleair Medicine, University Medical Center Utrecht, Utrecht, Netherlands; 4Research and Development, Mallinckrodt Medical BV, Covidien, Petten, Netherlands
The potential of MRI for dose calculations of Holmium-166 loaded microspheres to enable MR-based treatment planning of transcatheter radioembolization of hepatic malignancies was investigated. MRI and SPECT experiments were conducted using an anthropomorphic agarose gel phantom containing tumor-simulating gel samples with known amounts of 166Ho-PLLA-MS. Excellent agreement was observed both qualitatively and quantitatively when comparing MR-based to SPECT-based dose maps to reference data obtained with a dose calibrator. In conclusion, MR-based dosimetry of 166Ho-PLLA-MS was demonstrated to be feasible, indicating the potential of MR-based dosimetry for planning, guidance and evaluation of transcatheter radioembolization treatment of hepatic malignancies with 166Ho-PLLA-MS.