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Abstract #0256

Influence of Perfusion on Tissue Stiffness Assessed with MR Elastography

Meng Yin1, Kevin J. Glaser1, Arunark Kolipaka1, Lizette Warner2, Jayant A. Talwalkar3, Armando Manduca1, Richard L. Ehman1

1Department of Radiology, Mayo Clinic, Rochester, MN, United States; 2Division of Nephrology & Hypertension, Mayo Clinic, Rochester, MN, United States; 3Division of Gastroenterology, Mayo Clinic, Rochester, MN, United States

This preliminary investigation provides evidence that MRE-assessed hepatic and renal stiffness in two controlled animal models has a dynamic component that can increase or decrease following a fluctuation in perfusion. The use of MRE to assess changes in tissue mechanics associated with the dynamic perfusion of tissue provides new insights into the natural history and pathophysiology of hepatic and renal diseases and may have significant diagnostic value. Diagnostic and longitudinal MRE studies should take into account potential dynamic perfusion effects as a potential cause of variability.