Meng Yin1,
Kevin J. Glaser1, Arunark Kolipaka1, Lizette Warner2,
Jayant A. Talwalkar3, Armando Manduca1, Richard L.
Ehman1
1Department of Radiology, Mayo Clinic,
Rochester, MN, United States; 2Division of Nephrology &
Hypertension, Mayo Clinic, Rochester, MN, United States; 3Division
of Gastroenterology, Mayo Clinic, Rochester, MN, United States
This
preliminary investigation provides evidence that MRE-assessed hepatic and
renal stiffness in two controlled animal models has a dynamic component that
can increase or decrease following a fluctuation in perfusion. The use of MRE
to assess changes in tissue mechanics associated with the dynamic perfusion
of tissue provides new insights into the natural history and pathophysiology
of hepatic and renal diseases and may have significant diagnostic value.
Diagnostic and longitudinal MRE studies should take into account potential
dynamic perfusion effects as a potential cause of variability.