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Abstract #0259

T2 Relaxation Time as a Surrogate Marker of Liver Fibrosis

Luiz Siqueira1, Michael Chew1, Peter F. Hahn1, Giles Boland1, Lawrence T. White2, Deborah Gervais1, Peter R. Mueller1, Alexander R. Guimaraes2,3

1Radiology, Massachusetts General Hospital/Division of Abdominal Imaging, Boston, MA, United States; 2Radiology, Massachusetts General Hospital/Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 3Radiology, Division of Abdominal Imaging and Interventional Radiology, Boston, MA, United States

83 patients who underwent both liver MRI and liver biopsy for fibrosis staging within a 6 month period, between January 2004 and December 2008 were enrolled in this IRB approved retrospective study. All biopsies were staged histologically (Ishak classification system (0-6)) and grouped into mild (stage (1-2) n=20), moderate (stage (3-4), n=17), severe (stage (5-6), n=46). T2 relaxation time of liver parenchyma in patients was calculated by 2 point fit (mild 66.7 +/- 1.9msec; moderate 71.6 +/- 1.7msec; severe 72.4 +/- 1.4msec) with low standard error (~1.9msec), demonstrating statistically significant difference between degrees of mild vs. severe fibrosis (p<0.05).