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Abstract #0296

Acute Diffusion MRI Measurements Predict Chronic Axonal Function Assessed Using Electrophysiology

Joong Hee Kim1, David S. K. Magnuson2, Sheng-Kwei Song1

1Radiology, Washington University , St. Louis, MO, United States; 2Neurological Surgery and Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY, United States

Diffusion tensor imaging (DTI) has been widely employed to assess central nervous system white matter integrity in animal models and patients. Herein, we demonstrate for the first time that the axonal injury marker derived by DTI as early as 3 hours post-spinal cord contusion, a time point when no existing modality is capable of assessing underlying axonal injury or the neurological disability, reflects injury severity and accurately predicts long-term neurological function.