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Abstract #0298

Apparent Exchange Rate of Water in Human Brain Matter Revealed by a Novel Pulse Sequence

Markus Nilsson1, Daniel Topgaard2, Sara Brockstedt, Freddy Sthlberg1,3, Jimmy Ltt1,4

1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2Physical Chemistry, Lund University, Lund, Sweden; 3Department of Diagnostic Radiology, Lund University, Lund, Sweden; 4Center for Medical Imaging and Physiology, Lund University Hospital, Lund, Sweden

Results using a novel diffusion sensitive imaging sequence generating a potentially useful contrast mechanism: the apparent exchange rate of water, related to the and cell membrane permeability. Diagnostics and prediction of treatment outcome of various pathologies might benefit from the additional information gained by knowledge of the water exchange rate. The sequence was evaluated in phantom as well as in vivo.