Pl Erik Goa1,
Christian Brekken2, Anders Thorstensen2, Brage Hyem
Amundsen2, Asta Kristine Hberg3
1Dept. of Medical Imaging, St. Olavs
University Hospital, Trondheim, Norway; 2Dept. of Circulation and
Medical Imaging, Norwegian University of Science and Technology (NTNU),
Trondheim, Norway; 3Dept. of Neuromedicine, Norwegian University
of Science and Technology (NTNU), Trondheim, Norway
Whole-brain
T1-mapping was performed before and 1 day, 4 days and 7 days after
administration of clinical dosage of Teslascan in 8 healthy male volunteers.
ROI was defined in Hippocampus, Caudate Nucleus and Corpus Callosum, and the
T1 relaxation time at different timepoints after injection was compared to
baseline values. Only in hippocampus at day 1 after injection was a
statistically significant reduction in T1 observed. At later timepoints for
the hippocampus, and for caudate nucleus in general only a trend towards
reduced T1 was observed. For Corpus Callosum no T1 changes were observed.
Keywords