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Abstract #0312

Repeated T1 Mapping in Brain Following Clinical Dosage of Teslascan

Pl Erik Goa1, Christian Brekken2, Anders Thorstensen2, Brage Hyem Amundsen2, Asta Kristine Hberg3

1Dept. of Medical Imaging, St. Olavs University Hospital, Trondheim, Norway; 2Dept. of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 3Dept. of Neuromedicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Whole-brain T1-mapping was performed before and 1 day, 4 days and 7 days after administration of clinical dosage of Teslascan in 8 healthy male volunteers. ROI was defined in Hippocampus, Caudate Nucleus and Corpus Callosum, and the T1 relaxation time at different timepoints after injection was compared to baseline values. Only in hippocampus at day 1 after injection was a statistically significant reduction in T1 observed. At later timepoints for the hippocampus, and for caudate nucleus in general only a trend towards reduced T1 was observed. For Corpus Callosum no T1 changes were observed.