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Abstract #0317

Modeling of 13C MRS Data of Cerebral Glucose Metabolism Comparing Mild Hypoglycemia with Euglycemia in Humans

Kim C.C. van de Ven1, Marinette van der Graaf1,2, Alexander A. Shestov3, Bastiaan E. de Galan4, Cees J.J. Tack4, Pierre-Gilles Henry3, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Clinical Physics Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 3Center for Magnetic Resonance Research, University of Minneapolis, Minneapolis, MN, United States; 4General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands


During hypoglycemia the supply of the brain with glucose is reduced. The aim of this study was to examine the direct effects of hypoglycemia on cerebral glucose metabolism by 13C MRS with infusion of [1-13C]glucose. 13C-label from glucose gets incorporated into isotopic positions in downstream amino acids. To estimate metabolic kinetics the time dependent uptake curves were modeled with a one-compartment model of cerebral glucose metabolism. Assuming similar labeling in plasma [3-13C]lactate, the flux through the TCA cycle, given by VTCA , were comparable for both groups indicating that brain metabolism is maintained during mild hypoglycemia.