Kim C.C. van de Ven1, Marinette van der
Graaf1,2, Alexander A. Shestov3, Bastiaan E. de Galan4,
Cees J.J. Tack4, Pierre-Gilles Henry3, Arend Heerschap1
1Radiology, Radboud University Nijmegen
Medical Centre, Nijmegen, Netherlands; 2Clinical Physics
Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen,
Netherlands; 3Center for Magnetic Resonance Research, University
of Minneapolis, Minneapolis, MN, United States; 4General Internal
Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
During
hypoglycemia the supply of the brain with glucose is reduced. The aim of this
study was to examine the direct effects of hypoglycemia on cerebral glucose
metabolism by 13C MRS with infusion of [1-13C]glucose. 13C-label
from glucose gets incorporated into isotopic positions in downstream amino
acids. To estimate metabolic kinetics the time dependent uptake curves were
modeled with a one-compartment model of cerebral glucose metabolism. Assuming
similar labeling in plasma [3-13C]lactate, the flux through the
TCA cycle, given by VTCA , were comparable for both groups
indicating that brain metabolism is maintained during mild hypoglycemia.
Keywords