Kaspar
Josche Streitberger1, Friedemann Paul2, Dagmar Krefting3,
Dieter Klatt1, Sebastian Papazoglou1, Sebastian Hirsch1,
Jrgen Braun3, Ingolf Sack1
1Institute of Radiology, Charit -
University Medicine Berlin, Berlin, Germany; 2Neurocure, Charit -
University Medicine Berlin, Berlin, Germany; 3Institute of Medical
Informatics, Charit - University Medicine Berlin, Berlin, Germany
Chronic
inflammatory diseases of the CNS such as Multiple Sclerosis (MS) lead to
demyelinization and to widespread degradation of neurons and axons
processes which alter the mechanical consistency of the brain. In this study
MR elastography and MRI volumetry is used to investigate the alteration of
brain mechanics and brain geometry due to MS. A decrease in brain stiffness
of 17% accompanied by a loss of brain volume of 5% was measured in 17 MS
patients and 42 healthy volunteers.