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Abstract #0394

Vessel Size Index (VSI) MRI in Solid Tumours - Validation with Microvascular Corrosion Casts

Jake Samuel Burrell1, Jane Halliday2, Simon Walker-Samuel3, John C. Waterton2, Philip J. Withers4, Robert S. Bradley4, Jessica Boult1, Yann Jamin1, Lauren C. Baker1, Simon P. Robinson1

1The Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2AstraZeneca, Manchester, United Kingdom; 3UCL, London, United Kingdom; 4School of Materials, University of Manchester, Manchester, United Kingdom

Susceptibility contrast MRI vessel size index (VSI) derived vessel diameters were compared with vessel diameters measured from vascular corrosion casts of the same SW1222 colorectal tumours. Good agreement was found between the MRI and vascular corrosion cast derived vessel sizes, reported as 38 6m and 39 2m respectively. This work helps to qualify non-invasive MRI vessel size measurements with appropriate histology.