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Abstract #0412

Ultra-High Field Measurements of Glycogen, IMCL and Perfusion in Skeletal Muscle in Post-Exercise Recovery: A 13C and 1H MRS Study

Mary Charlotte Stephenson1, Frances Gunner2, Elizabeth J. Simpson2, Paul Greenhaff2, Susan T. Francis1, Ian A. MacDonald2, Peter G. Morris1

1SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2School of Biomedical Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

This study assesses the feasibility of sequentially monitoring muscle glycogen and IMCL levels, and perfusion, in exercising and non-exercising thigh muscles, prior to and following exercise at 7T. Levels of glycogen in exercising muscles decreased significantly during exercise, with larger decreases following higher intensity exercise. Carbohydrate re-feeding increased glycogen levels with levels returning towards baseline. Levels of glycogen in the non-exercising muscles showed no change following exercise and re-feeding. No significant changes in IMCL were measured. Perfusion data indicates an increase in muscle perfusion during exercise, however further analysis will be carried out to further improve results.