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Abstract #0414

Diffusion Tensor Imaging to Track Changes in Skeletal Muscle Architecture of Sarcopenic Rats

Ihssan S. Masad1,2, Jacob M. Wilson3, S-R Lee3, Y-M Park3, Paul C. Henning3, Bahram H. Arjmandi3, J-S Kim3, Samuel Colles Grant1,2

1Department of Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States; 2National High Magnetic field Laboratory, Tallahassee, FL, United States; 3Department of Nutrition, Food & Exercise Sciences, The Florida State University, Tallahassee, FL, United States

Diffusion tensor imaging (DTI) has demonstrated remarkable capability to assess cross-sectional areas (CSA) and myofiber architecture in muscle. However, DTI has not been applied to the study of age-related muscle wasting, known as sacropenia, in rodents. In this work, the effects of age on CSA and anisotropy of water diffusion in muscle are studied under the influence of advanced aging in rats. Results demonstrate that the soleus CSA and ADC decrease with age until reaching a plateau at advanced time points. FA increases with age until it also plateaus. These findings indicate that DTI is sensitive to sacropenic alterations.