Dimitrios C. Karampinos1, Huanzhou Yu2,
Ann Shimakawa2, Richard B. Souza1, Thomas M. Link1,
Xiaojuan Li1, Sharmila Majumdar1
1Radiology and Biomedical Imaging,
University of California, San Francisco, San Francisco, CA, United States; 2Applied
Science Laboratory, GE Healthcare, Menlo Park, CA, United States
IDEAL
gradient-echo imaging has been proposed for mapping the spatial distribution
and quantifying the amount of intermuscular adipose tissue (IMAT). However,
the large difference in T1 of muscle and fat can cause significant
overestimation in IDEAL fat fraction. In the present work, the use of a
precalibrated T1-corrected fat spectrum is proposed in order to
remove T1 bias in dual flip angle multi-peak T2* muscle
IDEAL. The noise performance of the technique is compared to the single small
flip angle approach. The technique is validated in a phantom and preliminary in vivo results are shown in the calf
muscle.