Kurt Hermann Bockhorst1, Harriet Charmaine
Rea2, Rui Liu3, Jarek Wosik3, Jose Regino
Perez-Polo2, Ponnada A. Narayana1
1Diagnostic and Interventional Imaging,
University of Texas, Houston, TX, United States; 2Biochemistry
& Molecular Biology, University of Texas Medical Branch, Galveston, TX,
United States; 3Electronics and Computer Science, University of
Houston, Houston, TX, United States
International
guidelines recommend the treatment of perinatal hypoxia with 100% oxygen.
This treatment is controversial. We therefore initiated a study of a neonatal
rat model, which is widely accepted for perinatal hypoxia in infants. Our
findings confirm the concerns, that hyperoximia actually exacerbates the
injuries caused by perinatal hypoxia