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Abstract #0466

Hyperoximic Therapy of Hypoxic Neonatals Increases Cerebral Injury. DTI Study in Rats

Kurt Hermann Bockhorst1, Harriet Charmaine Rea2, Rui Liu3, Jarek Wosik3, Jose Regino Perez-Polo2, Ponnada A. Narayana1

1Diagnostic and Interventional Imaging, University of Texas, Houston, TX, United States; 2Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, United States; 3Electronics and Computer Science, University of Houston, Houston, TX, United States

International guidelines recommend the treatment of perinatal hypoxia with 100% oxygen. This treatment is controversial. We therefore initiated a study of a neonatal rat model, which is widely accepted for perinatal hypoxia in infants. Our findings confirm the concerns, that hyperoximia actually exacerbates the injuries caused by perinatal hypoxia