Thomas Tourdias1, Iulius Dragonu2,
Nadge Cassagno1, Mathilde Deloire-Grassin1, Claudine
Boiziau1, Bruno Brochet1, Chrit Moonen2,
Klaus Petry1, Vincent Dousset1
1Laboratoire de Neurobiologie des
affections de la myline, EA2966, (1) Universit
Victor Segalen Bordeaux 2, Bordeaux, France; 2UMR-CNRS 5231,
laboratoire dimagerie molculaire et fonctionnelle, (1) Universit Victor Segalen Bordeaux 2,
Bordeaux, France
We
combined MRI, histology and molecular biology to assess the time course of
aquaporin 4 (AQP4) expression during brain inflammation in the rat brain. We
reported a moderate AQP4 up-regulation during the active phase of
inflammation that was insufficient to remove interstitial water excess as
assessed by diffusion MRI. We found a second AQP4 up-regulation that was
delayed and with a different pattern, i.e. pan astrocytic and not confined to
the blood brain barrier interface. Again, this delayed up-regulation was
insufficient to remove vasogenic edema but was probably involved in the glial
scar formation.
Keywords