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Abstract #0470

Biphasic Expression of Aquaporin 4 During the Course of Brain Inflammation

Thomas Tourdias1, Iulius Dragonu2, Nadge Cassagno1, Mathilde Deloire-Grassin1, Claudine Boiziau1, Bruno Brochet1, Chrit Moonen2, Klaus Petry1, Vincent Dousset1

1Laboratoire de Neurobiologie des affections de la myline, EA2966, (1) Universit Victor Segalen Bordeaux 2, Bordeaux, France; 2UMR-CNRS 5231, laboratoire dimagerie molculaire et fonctionnelle, (1) Universit Victor Segalen Bordeaux 2, Bordeaux, France

We combined MRI, histology and molecular biology to assess the time course of aquaporin 4 (AQP4) expression during brain inflammation in the rat brain. We reported a moderate AQP4 up-regulation during the active phase of inflammation that was insufficient to remove interstitial water excess as assessed by diffusion MRI. We found a second AQP4 up-regulation that was delayed and with a different pattern, i.e. pan astrocytic and not confined to the blood brain barrier interface. Again, this delayed up-regulation was insufficient to remove vasogenic edema but was probably involved in the glial scar formation.