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Abstract #0479

Does Quantification of T2 SNR Decrease After USPIO Administration Allow Differentiation Between Benign and Malignant Normal Sized Pelvic Lymph Nodes?

Johannes M. Froehlich1, Benedikt Rckriem1, Maria Triantafyllou1, Frederic D. Birkhaeuser2, Michael von Gunten3, Peter Vermathen4, Harriet C. Thoeny1

1Institute of Diagnostic, Interventional and Pediatric Radiology, University Hospital, Bern, Switzerland; 2Department of Urology, University Hospital, Bern, Switzerland; 3Institute of Pathology, University Hospital, Bern, Switzerland; 4Department of Clinical Research, University Hospital, Bern, Switzerland

Methodologically the staging of lymph nodes based on uptake of USPIO is judged on a qualitative level analyzing signal decrease and distribution on T2/T2*-weighted sequences. Quantification of SI/SNR-decrease in 320 lymph nodes comprising 20 malignant lymph nodes, 57 benign inguinal and 243 benign iliacal lymph nodes revealed significant differences (p<0.05) when comparing benign with malignant lymph nodes. Contrary to iliacal lymph nodes (24.8% 54.6%) inguinal ones presented limited SNR decrease (3.4% 55.4%). Substantial overlap of single data, limit the diagnostic potential of quantification. In practice morphological criteria, fatty content and localization of lymph nodes must be considered.