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Abstract #0513

MR Elastography of Stroke: A Feasibility Study

Sebastian Hirsch1, Kaspar Josche Streitberger1, Jan Rodrigo Hoffmann2, Randolf Klingebiel3, Dieter Klatt1, Sebastian Papazoglou1, Jrgen Braun4, Ingolf Sack1

1Institute of Radiology, Charit - University Medicine Berlin, Berlin, Germany; 2Institute of Neurology, Charit - University Medicine Berlin, Berlin, Germany; 3Institute of Neuroradiology, Charit - University Medicine Berlin, Berlin, Germany; 4Institute of Medical Informatics, Charit - University Medicine Berlin, Berlin, Germany


The characterization of neuronal tissue inside an infarcted region is still a subject of intense research. MR elastography (MRE) is capable of measuring the mechanical connectivity of soft tissue in vivo. This feasibility study aims to assess the potential of MRE for the characterization of tissue regeneration after stroke. The hypothesis was that stroke-related changes of the biomechanical properties of neuronal tissue are detectable by MRE. The results demonstrate through both a decrease in the complex shear modulus and an increase in shear wave amplitudes that tissue integrity is degraded inside a stroke region.

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