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Abstract #0522

Voxel Based Perfusion Variability in ASL

Sanna Gevers1, Matthias J.P. van Osch2, Jeroen Hendrikse3, Reinoud P. Bokkers3, Dennis Kies2, Wouter M. Teeuwisse2, Charles B.L.M. Majoie1, Aart J. Nederveen4

1Radiology, Academic Medical Center Amsterdam, Amsterdam, Netherlands; 2Radiology, Leiden University Medical Center, Netherlands; 3Radiology, University Medical Center Utrecht, Netherlands; 4Radiology, Academic Medical Center Amsterdam, Netherlands

Thus far, ASL variability studies have mainly focussed on intrasession and intracenter and multicenter variability of global perfusion and of perfusion in the flow territories of major brain feeding arteries. The purpose of this study was to analyze variability patterns over different brain regions performing a voxel based analysis of variance within and between imaging sessions. The results of our study show that pseudo-continuous ASL with background suppression is least variable over different brain regions whereas other ASL techniques show more variability mainly in vascular regions. Most striking per voxel variances were found in the posterior circulation for pulsed ASL and in the frontal region for continuous ASL.