Meeting Banner
Abstract #0535

Quantitative Comparison of T1ρ with T2 in Intervertebral Disc in Vivo at 3T

Queenie Chan1,2, Mina Kim2, Marina-Portia Anthony2, Kenneth MC Cheung3, Aaron Chan2, Tao Chan2, Pek-Lan Khong2

1Philips Healthcare, Hong Kong, China; 2Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China; 3Division of Spine Surgery, Department of Orthopaedics and Traumatology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Diagnostic techniques based on conventional T2-weighted images are commonly used for disc degeneration but are subjective and not sensitive to subtle changes in the intervertebral discs (IVDs). Therefore, quantitative assessment would play an important role in greatly improving the evaluation of disc degeneration. In this study, we performed quantitative T1ρ and T2 measurements in human lumbar IVDs. Our results suggest that different degenerative-related changes taking place in between the central nucleus pulposus and the outer annulus fibrosus can be quantitatively assessed using T1ρ and T2 mapping which may provide complementary information to better understand pathophysiological mechanisms in disc degeneration.