Puneet Sharma1, Hiroumi D. Kitajima1,
Khalil N. Salman2, Bobby Kalb3, Diego R. Martin3
1Radiology, Emory Healthcare, Atlanta,
GA, United States; 2Radiology, Emory University, Atlanta, GA,
United States; 3Radiology, Emory University School of Medicine,
Atlanta, GA, United States
This
investigation analyzes use of a fast T2-corrected MRS method (HISTO) for the
simultaneous measurement of hepatic lipid and iron. The multi-echo
acquisition allows correction of lipid fraction, while providing R2 measures
of water and lipid separately. HISTO was performed in lipid phantoms with
variable iron content, and in 3 patients with induced iron susceptibility. It
was found that R2-water exhibited strong correlation with iron amount, while
R2-lipid showed no dependence, suggesting compartmental division of iron
effects. Since imaging evaluates bulk R2*, correlation with iron may be
influenced by lipid content. HISTO isolates R2-water and R2-lipid for robust
iron assessment.
Keywords