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Abstract #0555

Simultaneous Measurement of Hepatic Lipid and Iron with High-Speed T2-Corrected Single-Voxel Spectroscopy (HISTO): Analysis of Water-Lipid Compartments

Puneet Sharma1, Hiroumi D. Kitajima1, Khalil N. Salman2, Bobby Kalb3, Diego R. Martin3

1Radiology, Emory Healthcare, Atlanta, GA, United States; 2Radiology, Emory University, Atlanta, GA, United States; 3Radiology, Emory University School of Medicine, Atlanta, GA, United States

This investigation analyzes use of a fast T2-corrected MRS method (HISTO) for the simultaneous measurement of hepatic lipid and iron. The multi-echo acquisition allows correction of lipid fraction, while providing R2 measures of water and lipid separately. HISTO was performed in lipid phantoms with variable iron content, and in 3 patients with induced iron susceptibility. It was found that R2-water exhibited strong correlation with iron amount, while R2-lipid showed no dependence, suggesting compartmental division of iron effects. Since imaging evaluates bulk R2*, correlation with iron may be influenced by lipid content. HISTO isolates R2-water and R2-lipid for robust iron assessment.