J. Jean Chen1, H. Diana Rosas, 12, David H. Salat1
1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; 2Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Accurate measurement of regional cerebral blood flow (CBF) changes in aging using conventional techniques is hampered by low repeatability and partial-volume effects. In this work, we examine the feasibility of pulsed arterial-spin labelling in obtaining quantitative CBF maps in healthy adults, evaluating the impact of potential partial-volume effects and the robustness of calibration techniques. We observed cortical CBF decrease with healthy aging, with heightened reduction co-localizing with regions previously reported to exhibit decline in metabolism. These findings were independent of the choice of CBF calibration technique, and partial-volume effects were found to bias CBF in areas of significant cortical thinning.