Abstract #0613

DCE MRI Derived Kep Is a Surrogate Marker of MMP-9 Expression in Patients with Glioblastoma Multiforme

Rishi Awasthi¹, Nuzhat Husain², Priyanka Soni², Prativa Sahoo³, Sanjay Behari⁴, Shaleen Kumar⁵, Rakesh Pandey⁶, Ram Kishore Singh Rathore³, Rakesh Kumar Gupta¹

¹Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; ²Pathology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, UP, India, Lucknow, Uttar Pradesh, India; ³Mathematics and Statistics, Indian Institute of technology Kanpur, Kanpur, Uttar Pradesh, India; ⁴Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; ⁵Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; ⁶Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

DCE-MRI was performed on 17 patients with Glioblastoma multiforme (GBM). Various perfusion metrics were analyzed and correlated with immunohistochemically obtained MMP-9 expression. Among the perfusion metrics, Kep was found to have the best correlation with MMP-9 expression suggesting that it can be used as a surrogate for MMP-9 expression. A total of 8 patients were also followed up clinically to observe the duration of survival. The MMP-9 expression and quantified perfusion metrics were also correlated with the duration of survival. MMP-9 expression showed a significant negative correlation with the duration of survival indicating the possible role of MMP-9 in tumor progression as one of the factors. The Kep, Ktrans, Ve, rCBV and rCBF also correlated significantly with the duration of survival proving the utility of DCE MRI in forecasting tumor progression in malignant glioma. We suggest that Kep holds promise as a surrogate for MMP9 expression in GBM.