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Abstract #0622

Improving DSC-MRI by Orientation-Corrected Phase-Based AIF and VOF

Matus Straka1, Rexford D. Newbould2, Milos Sramek3, Gregory W. Albers4, Roland Bammer1

1Radiology, Stanford University, Stanford, CA, United States; 2Clinical Imaging Centre, GlaxoSmithKline, London, United Kingdom; 3Commision for Scientific Visualization, Austrian Academy Of Sciences, Vienna, Austria; 4Stroke Center, Stanford University Medical Center, Stanford, CA, United States

Quantitative perfusion measurements require accurate measurements of tracer concentration. Magnitude T2*-based data suffer from various artifacts and non-linearities and make quantification of (mainly vascular) tracer concentration difficult. Concentration can be derived from change in resonante frequency (phase of MR signal), however this effect depends on orientation of given vessel versus main magnetic field. Image-based filtering to enhance cylindrical structures is used to estimate vessel orientation from DSC-MRI data. This information is used to correct the phase information and improve quantification of Gd concentration in large vessels.