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Abstract #0663

MRI Assessment of Endothelial Damage and Angiogenesis in Porcine Coronary Arteries Using Gadofosveset

Steen Fjord Pedersen1, William P. Paaske2, Troels Thiem3, Steffen Ringgaard4, Samuel A Thryse4, Won Yong Kim5

1Aarhus University Hospital, Aarhus, Denmark; 21Dept. of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital, Skejby, Denmark; 3Dept. of Cardiology, Aarhus University Hospital, Skejby, Denmark; 4MR-center, Aarhus University Hospital, Skejby, Denmark; 5Dept. of Cardiology, and MR-center, Aarhus University Hospital, Skejby, Denmark

Endothelial damage and angiogenesis are essential in atherosclerotic plaque development and destabilization .We sought to examine whether contrast enhanced MRI using gadofosveset would enable the detection of endothelial damage and neovessels in balloon injured porcine coronary arteries. MRI showed contrast enhancement of the injured vs. the non-injured control artery with a significant increase in the diameter of (3019 % versus 48%; P=0.01). Ex-vivo coronary vessel wall MRI contrast enhancement was in agreement with extravasated Evans blue with a kappa value of 0.64 (p<0.001). and there was a linear correlation between coronary MRI contrast-enhancement and microvessel density (r=0.78, p<0.001).