Friedrich Wetterling1, Lindsay Gallagher2,
1School of Physics, Trinity College Dublin, Dublin, Ireland; 2Glasgow Experimental MRI Centre, , Division of Clinical Neuroscience, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom; 3Glasgow Experimental MRI Centre, Division of Clinical Neuroscience, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom; 4Bruker BioSpin GmbH, Ettlingen, Germany; 5Centre for Advanced Medical Imaging, St. Jamess Hospital, Dublin, Ireland
In the current study, quantitative 23Na Magnetic Resonance Microscopy (qNa MRM) was used to measure the time course of Tissue Sodium Concentration (TSC) in order to investigate regional variations in TSC behavior in the first 8 hours after stroke in a rodent model. The timecourse of the TSC evolution was reproducible (n=5) with similar regional delays evident in the timepoint at which the TSC increased during the first hours after MCAO in each rat. The delay time parameter could be used as a measure of ischaemic core tissue growth, non-invasively and temporally resolved, thereby offering an alternative method to post-mortem histology.